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Gamma interferon in antiviral defense

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Published by Landes in New York :$bChapman & Hall, Austin .
Written in English


  • Antiviral Agents.,
  • Interferon Type II.,
  • Interferon.,
  • Virus Diseases.,
  • Virus diseases -- Immunological aspects.

Book details:

Edition Notes

Includes bibliographical references and index.

Statement[edited by] Gunasegaran Karupiah.
SeriesMedical intelligence unit
ContributionsKarupiah, Gunasegaran, 1959-
LC ClassificationsQR187.5 .G36 1997
The Physical Object
Pagination192 p. :$bill.
Number of Pages192
ID Numbers
Open LibraryOL17043029M
ISBN 101570594341

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Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors. Institute of Experimental Immunology, University of Zürich, Switzerland. This article has been cited by other articles in PMC. Abstract. Alpha/beta interferon (IFN) and gamma IFN exert widely overlapping biological by: Gamma interferon is a major mediator of antiviral defense in experimental measles virus-induced encephalitis Article (PDF Available) in Journal of Virology 69(9) . Antiviral Defense in Mice Lacking Both Alpha/Beta and Gamma-Interferon Receptors Article (PDF Available) in Journal of Virology 69(8) . Alpha/beta interferon (IFN) and gamma IFN exert widely overlapping biological effects. Still, mice with individually inactivated alpha/beta or gamma receptors exhibit variably severely reduced resistance to infection and altered immune responses. To investigate to what extent the two IFN systems are functionally redundant, we generated mice with a combined receptor defect Cited by:

Interferon-gamma increases expression of class II MHC molecules on antigen-presenting cells and thus promotes presentation of antigens to helper T cells. Interferon-gamma can also activate the ability of macrophages to resist viral infection (intrinsic antiviral activity) and to kill other cells if they are infected (extrinsic antiviral activity).   Interferon-gamma (IFNG) was first discovered as a soluble macromolecule with antiviral activity. In contrast to virally induced interferon (IFN) (2), it was produced from leukocytes upon stimulation with phytohemagglutinin, a mitogenic plant lectin (1).Cited by:   Gamma interferon (IFN-γ) is an important cytokine in the host defense against infection by viral and microbial pathogens. IFN-γ induces a variety of physiologically significant responses that contribute to by: Review Department of Surgery, Erasmus University, Rotterdam, The Netherlands Interferon-gamma: A Review JAN N. M. IJZERMANS and RICHARD L. MARQUET Received March 8,' Accepted in Revised Form J Introduction In , ISAACS and LINDENMANN (1) discovered a protein, designated interferon(IFN), that could confer resistance upon cells Cited by:

  Gamma interferon (IFNγ) was discovered in as an antiviral activity in white blood cell cultures stimulated with the lymphocyte mitogen phytohemagglutinin. At that time, IFNγ, as was the case with the much earlier discovered type I IFNs, was thought to strictly function as an by: 2. Antiviral proteins encoded by the interferon (IFN)-stimulated genes provide a front-line defense against viral infections. In particular, PKR, RNase L, and Mx are considered to be the principal proteins through which IFNs mount an antiviral state. To determine whether alternative antiviral pathways exist, Cited by: Interferon was discovered by Alick Isaacs and Jean Lindenmann in It was originally thought that interferon could be used as a general anti-viral agent and in anti-cancer therapy. The main reason is that our body is not defenseless but makes use of numerous measures to keep viruses at bay. As we know, the type I interferon system is a major player in antiviral defense against all kinds of viruses. Virus-infected cells synthesize and secrete type I interferons (IFN-α/β) which warn the body of the dangerous by: